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Shimada said the process may be applicable to humans and other species if the receptors are found to be present on human sperm. The team acknowledges that the possibility of using the technique in humans comes with ethical problems, though these are not new. Embryos produced through IVF can already be screened for their sex. While in some countries including the US parents can use this to choose the sex of their child, in the UK it is illegal to select which embryo to implant based on its sex unless there are medical reasons.
Prof Robin Lovell-Badge, an expert in developmental biology at the Francis Crick Institute in London, said the research could prove very useful if similar effects are seen in farm animals. He added it may also help solve the puzzle of why, even in nature, sex ratios in some mammals can shift away from under certain environmental conditions, noting there is some evidence that in humans stress can have such an effect. Similar results were found for another drug that only binds to TLR7 receptors.
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